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Nuclear Receptor

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  1. Content type: Research

    Common variants of the PPARA gene have been found to associate with ischaemic heart disease in non diabetic men. The L162V variant was found to be protective while the C2528G variant increased risk. L162V has als...

    Authors: Alex SF Doney, Bettina Fischer, Simon P Lee, Andrew D Morris, Graham Leese and Colin NA Palmer

    Citation: Nuclear Receptor 2005 3:4

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  2. Content type: Research

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. To identify human PPARs-responsive gen...

    Authors: Keisuke Tachibana, Yumi Kobayashi, Toshiya Tanaka, Masayuki Tagami, Akira Sugiyama, Tatsuya Katayama, Chihiro Ueda, Daisuke Yamasaki, Kenji Ishimoto, Mikako Sumitomo, Yasutoshi Uchiyama, Takahide Kohro, Juro Sakai, Takao Hamakubo, Tatsuhiko Kodama and Takefumi Doi

    Citation: Nuclear Receptor 2005 3:3

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  3. Content type: Research

    The nuclear hormone receptor (NR) superfamily complement in humans is composed of 48 genes with diverse roles in metabolic homeostasis, development, and detoxification. In general, NRs are strongly conserved b...

    Authors: Matthew D Krasowski, Kazuto Yasuda, Lee R Hagey and Erin G Schuetz

    Citation: Nuclear Receptor 2005 3:2

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  4. Content type: Research

    There is a substantial clinical overlap between chronic renal failure (CRF) and hypothyroidism, suggesting the presence of hypothyroidism in uremic patients. Although CRF patients have low T3 and T4 levels with n...

    Authors: Guilherme M Santos, Carlos J Pantoja, Aluízio Costa e Silva, Maria C Rodrigues, Ralff C Ribeiro, Luiz A Simeoni, Noureddine Lomri and Francisco AR Neves

    Citation: Nuclear Receptor 2005 3:1

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  5. Content type: Research

    Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals. In non-mammalian species, only one...

    Authors: Christoph Handschin, Sharon Blättler, Adrian Roth, Renate Looser, Mikael Oscarson, Michel R Kaufmann, Michael Podvinec, Carmela Gnerre and Urs A Meyer

    Citation: Nuclear Receptor 2004 2:7

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  6. Content type: Research

    The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes.

    Authors: Yuichiro Kanno, Satoshi Otsuka, Takuya Hiromasa, Takayuki Nakahama and Yoshio Inouye

    Citation: Nuclear Receptor 2004 2:6

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  7. Content type: Research

    Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase respo...

    Authors: Romi Ghose, Tracy L Zimmerman, Sundararajah Thevananther and Saul J Karpen

    Citation: Nuclear Receptor 2004 2:4

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  8. Content type: Research

    Estrogen receptors alpha and beta (ERα and ERβ) differentially activate genes with AP-1 elements. ERα activates AP-1 targets via activation functions with estrogens (the AF-dependent pathway), whereas ERβ, and...

    Authors: Rosalie M Uht, Paul Webb, Phuong Nguyen, Richard H Price Jr Jr, Cathleen Valentine, Helene Favre and Peter J Kushner

    Citation: Nuclear Receptor 2004 2:2

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  9. Content type: Research

    The constitutive androstane receptor (CAR) plays a key role in the control of drug metabolism and transport by mediating the phenobarbital-type induction of many phase I and II drug metabolizing enzymes and dr...

    Authors: Katja A Arnold, Michel Eichelbaum and Oliver Burk

    Citation: Nuclear Receptor 2004 2:1

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  10. Content type: Research

    PPARδ (NR1C2) promotes lipid accumulation in human macrophages in vitro and has been implicated in the response of macrophages to vLDL. We have investigated the role of PPARδ in PMA-stimulated macrophage differen...

    Authors: Helen Vosper, Guennadi A Khoudoli and Colin NA Palmer

    Citation: Nuclear Receptor 2003 1:9

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  11. Content type: Review

    Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed a central role in the development and differentiation of steroidogenic tissues. SF-1 controls the expression of all ...

    Authors: Pierre Val, Anne-Marie Lefrançois-Martinez, Georges Veyssière and Antoine Martinez

    Citation: Nuclear Receptor 2003 1:8

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  12. Content type: Research

    The specificity of a nuclear receptor's ability to modulate gene expression resides in its ability to bind a specific lipophilic ligand, associate with specific dimerization partners and bind specific DNA sequ...

    Authors: Kenneth W Henry II, Michael L Spencer, Maria Theodosiou, Dingyuan Lou and Daniel J Noonan

    Citation: Nuclear Receptor 2003 1:7

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  13. Content type: Research

    Retinoic acid receptors (RARs) are ligand-regulated transcription factors controlling cellular proliferation and differentiation. Receptor-interacting proteins such as corepressors and coactivators play a cruc...

    Authors: Perrine J Martin, Marie-Hélène Delmotte, Pierre Formstecher and Philippe Lefebvre

    Citation: Nuclear Receptor 2003 1:6

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  14. Content type: Research

    Hepatocyte nuclear factor-4α (HNF4α; NR2A1) is an orphan member of the nuclear receptor superfamily involved in various processes that could influence endoderm development, glucose and lipid metabolism. A loss...

    Authors: Shuying Jiang, Toshiya Tanaka, Hiroko Iwanari, Hiromitsu Hotta, Hisahiko Yamashita, Junko Kumakura, Yuichiro Watanabe, Yasutoshi Uchiyama, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko Kodama and Makoto Naito

    Citation: Nuclear Receptor 2003 1:5

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  15. Content type: Research

    Nuclear receptors (NRs) usually bind the corepressors N-CoR and SMRT in the absence of ligand or in the presence of antagonists. Agonist binding leads to corepressor release and recruitment of coactivators. He...

    Authors: Paul Webb, Cathleen Valentine, Phuong Nguyen, Richard H Price Jr, Adhirai Marimuthu, Brian L West, John D Baxter and Peter J Kushner

    Citation: Nuclear Receptor 2003 1:4

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  16. Content type: Research

    Steroid hormone receptors (SHRs) are members of the superfamily of ligand-activated transcription factors that regulate many biological processes. Co-regulators act as bridging molecules between the SHR and ge...

    Authors: Fernando de Miguel, Soo Ok Lee, Sergio A Onate and Allen C Gao

    Citation: Nuclear Receptor 2003 1:3

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  17. Content type: Research

    CAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist lig...

    Authors: Iphigenia Tzameli, Steven S Chua, Boris Cheskis and David D Moore

    Citation: Nuclear Receptor 2003 1:2

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  18. Content type: Research

    Liver X activated receptor alpha (LXRα) forms a functional dimeric nuclear receptor with RXR that regulates the metabolism of several important lipids, including cholesterol and bile acids. As compared with RX...

    Authors: Yuichiro Watanabe, Toshiya Tanaka, Yasutoshi Uchiyama, Tetsu Takeno, Akashi Izumi, Hisahiko Yamashita, Junko Kumakura, Hiroko Iwanari, Jiang Shu-Ying, Makoto Naito, David J Mangelsdorf, Takao Hamakubo and Tatsuhiko Kodama

    Citation: Nuclear Receptor 2003 1:1

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