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  1. Research

    Association of common variation in the PPARAgene with incident myocardial infarction in individuals with type 2 diabetes: A Go-DARTS study

    Common variants of the PPARA gene have been found to associate with ischaemic heart disease in non diabetic men. The L162V variant was found to be protective while the C2528G variant increased risk. L162V has als...

    Alex SF Doney, Bettina Fischer, Simon P Lee, Andrew D Morris, Graham Leese and Colin NA Palmer

    Nuclear Receptor 2005 3:4

    Published on: 25 November 2005

  2. Research

    Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. To identify human PPARs-responsive gen...

    Keisuke Tachibana, Yumi Kobayashi, Toshiya Tanaka, Masayuki Tagami, Akira Sugiyama, Tatsuya Katayama, Chihiro Ueda, Daisuke Yamasaki, Kenji Ishimoto, Mikako Sumitomo, Yasutoshi Uchiyama, Takahide Kohro, Juro Sakai, Takao Hamakubo, Tatsuhiko Kodama and Takefumi Doi

    Nuclear Receptor 2005 3:3

    Published on: 3 October 2005

  3. Research

    Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors)

    The nuclear hormone receptor (NR) superfamily complement in humans is composed of 48 genes with diverse roles in metabolic homeostasis, development, and detoxification. In general, NRs are strongly conserved b...

    Matthew D Krasowski, Kazuto Yasuda, Lee R Hagey and Erin G Schuetz

    Nuclear Receptor 2005 3:2

    Published on: 30 September 2005

  4. Research

    Thyroid hormone receptor binding to DNA and T3-dependent transcriptional activation are inhibited by uremic toxins

    There is a substantial clinical overlap between chronic renal failure (CRF) and hypothyroidism, suggesting the presence of hypothyroidism in uremic patients. Although CRF patients have low T3 and T4 levels with n...

    Guilherme M Santos, Carlos J Pantoja, Aluízio Costa e Silva, Maria C Rodrigues, Ralff C Ribeiro, Luiz A Simeoni, Noureddine Lomri and Francisco AR Neves

    Nuclear Receptor 2005 3:1

    Published on: 4 April 2005

  5. Research

    The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

    Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals. In non-mammalian species, only one...

    Christoph Handschin, Sharon Blättler, Adrian Roth, Renate Looser, Mikael Oscarson, Michel R Kaufmann, Michael Podvinec, Carmela Gnerre and Urs A Meyer

    Nuclear Receptor 2004 2:7

    Published on: 12 October 2004

  6. Research

    Diurnal difference in CAR mRNA expression

    The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes.

    Yuichiro Kanno, Satoshi Otsuka, Takuya Hiromasa, Takayuki Nakahama and Yoshio Inouye

    Nuclear Receptor 2004 2:6

    Published on: 28 August 2004

  7. Research

    Endotoxin leads to rapid subcellular re-localization of hepatic RXRα: A novel mechanism for reduced hepatic gene expression in inflammation

    Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase respo...

    Romi Ghose, Tracy L Zimmerman, Sundararajah Thevananther and Saul J Karpen

    Nuclear Receptor 2004 2:4

    Published on: 16 August 2004

  8. Research

    A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interactions with a modulating repressor

    Estrogen receptors alpha and beta (ERα and ERβ) differentially activate genes with AP-1 elements. ERα activates AP-1 targets via activation functions with estrogens (the AF-dependent pathway), whereas ERβ, and...

    Rosalie M Uht, Paul Webb, Phuong Nguyen, Richard H Price Jr Jr, Cathleen Valentine, Helene Favre and Peter J Kushner

    Nuclear Receptor 2004 2:2

    Published on: 7 May 2004

  9. Research

    PLZF is a negative regulator of retinoic acid receptor transcriptional activity

    Retinoic acid receptors (RARs) are ligand-regulated transcription factors controlling cellular proliferation and differentiation. Receptor-interacting proteins such as corepressors and coactivators play a cruc...

    Perrine J Martin, Marie-Hélène Delmotte, Pierre Formstecher and Philippe Lefebvre

    Nuclear Receptor 2003 1:6

    Published on: 6 September 2003

  10. Research

    Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats

    Hepatocyte nuclear factor-4α (HNF4α; NR2A1) is an orphan member of the nuclear receptor superfamily involved in various processes that could influence endoderm development, glucose and lipid metabolism. A loss...

    Shuying Jiang, Toshiya Tanaka, Hiroko Iwanari, Hiromitsu Hotta, Hisahiko Yamashita, Junko Kumakura, Yuichiro Watanabe, Yasutoshi Uchiyama, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko Kodama and Makoto Naito

    Nuclear Receptor 2003 1:5

    Published on: 8 August 2003

  11. Research

    ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus

    Nuclear receptors (NRs) usually bind the corepressors N-CoR and SMRT in the absence of ligand or in the presence of antagonists. Agonist binding leads to corepressor release and recruitment of coactivators. He...

    Paul Webb, Cathleen Valentine, Phuong Nguyen, Richard H Price Jr, Adhirai Marimuthu, Brian L West, John D Baxter and Peter J Kushner

    Nuclear Receptor 2003 1:4

    Published on: 28 June 2003

  12. Research

    Stat3 enhances transactivation of steroid hormone receptors

    Steroid hormone receptors (SHRs) are members of the superfamily of ligand-activated transcription factors that regulate many biological processes. Co-regulators act as bridging molecules between the SHR and ge...

    Fernando de Miguel, Soo Ok Lee, Sergio A Onate and Allen C Gao

    Nuclear Receptor 2003 1:3

    Published on: 13 June 2003

  13. Research

    Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages

    Liver X activated receptor alpha (LXRα) forms a functional dimeric nuclear receptor with RXR that regulates the metabolism of several important lipids, including cholesterol and bile acids. As compared with RX...

    Yuichiro Watanabe, Toshiya Tanaka, Yasutoshi Uchiyama, Tetsu Takeno, Akashi Izumi, Hisahiko Yamashita, Junko Kumakura, Hiroko Iwanari, Jiang Shu-Ying, Makoto Naito, David J Mangelsdorf, Takao Hamakubo and Tatsuhiko Kodama

    Nuclear Receptor 2003 1:1

    Published on: 9 May 2003

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