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Table 6 Prospective model of PPARA variants and non-fatal myocardial infarction risk in the Go-DARTs cohort. A full set of data was available on 1806 individuals, 108 recorded non fatal myocardial infarctions during the period of observation, with a total of 94497.6 months of observation. Both PPARA variants were analysed using a co-dominant model.

From: Association of common variation in the PPARAgene with incident myocardial infarction in individuals with type 2 diabetes: A Go-DARTS study

 

Hazard Ratio

95% CI

P

V162

0.31

0.10 0.93

0.037

C2528

2.77

1.34 5.75

0.006

Smoking

1.39

0.93 2.10

0.112

Gender

0.72

0.48 1.08

0.107

Age at recruitment

1.05

1.02 1.07

<0.001

Insulin treatment

2.56

1.69 3.89

<0.001

Prevalent angina

5.64

3.80 8.40

<0.001

Prevalent cerebrovascular disease

1.29

0.67 2.51

0.445

Prevalent myocardial infarction

3.90

2.60 5.81

<0.001

Haplotypes

   

L162-G2582

Ref

  

L162-C2528

1.68

1.16–2.43

0.006

V162-G2528

0.54

0.20–1.48

0.23

V162-C2528

0.96

0.48–1.94

0.91