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Figure 2 | Nuclear Receptor

Figure 2

From: The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

Figure 2

Reduced drug-induction of drug-responsive enhancer elements from CYP2H1, CYP3A37, CYP2C45 and ALAS1 in LMH cells stably expressing CXR RNAi. A, mRNA levels of endogenous CXR in LMH cells expressing pSUPER expression vector or CXR RNAi. CXR levels were measured by real-time PCR in LMH cells that stably express control vector or CXR RNAi. B–E, Phenobarbital-induction of drug-responsive enhancer elements from CYP2H1 (B), CYP3A37 (C), CYP2C45 (D) and ALAS1 (E) in LMH cells expressing pSUPER or CXR RNAi. LMH cells were transfected with the reporter gene plasmids and subsequently treated with vehicle or 400 μM PB for 16 hours before reporter gene levels were determined.

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