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Figure 4 | Nuclear Receptor

Figure 4

From: A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interactions with a modulating repressor

Figure 4

The ERβ.K170A mutation reverses ERβ ligand activation profile at AP-1. (A) Results of a HeLa cell transfection in which activity of ERβ (530 amino acid isoform) and an equivalent K170A mutation (shown in schematic at left) are compared at an AP-1 responsive reporter (Coll73-Luc). (B) Results of a similar HeLa cell transfection in which the full ligand activation profile of the ERα DBD-LBD region and its K206A equivalent are compared at AP-1 sites.

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