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Figure 1 | Nuclear Receptor

Figure 1

From: Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

Figure 1

Genomic organization and structure of alternatively spliced transcripts of human CAR(A) Genomic organization of the gene (top) and structure of transcripts (bottom). Exons are depicted as open boxes. Introns are shown by horizontal lines. Extension of exons 7 and 8 by use of alternative intronic 3' splice sites is depicted by black boxes. The 5' part of exon 9 which is deleted by use of an alternative 3'splice site within the exon is shown by a gray box with dotted line. Start and stop codons are indicated. TGA* indicates the stop codon of transcripts with the deletion in exon 9. Arrowheads represent the position of the indicated primers (see Table 1). Alternatively spliced transcripts are referred to as SV1 to SV12. (B) Detailed description of the alternative splicing in exon 9. An alternative 3'splice site resides within exon 9. Use of this site results in the out-of-frame deletion of the first 76 bp of the exon. 5' and 3' splice sites are shown in bold lower case letters. Exon sequences represented in the transcripts with the deletion are in upper case letters. Encoded amino acids are shown below. The asterisk denotes the new stop codon.

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