SF-1 a key player in the development and differentiation of steroidogenic tissues

Val, Pierre; Lefrançois-Martinez, Anne-Marie; Veyssière, Georges; Martinez, Antoine

doi:10.1186/1478-1336-1-8

Nuclear Receptor

Table 3 Transcription factors or cofactors that interact with SF-1. For each interacting factor, the resulting functional interaction, the experimental approach used to evidence the physical interaction and the model promoter are indicated.

From: SF-1 a key player in the development and differentiation of steroidogenic tissues

Factor	Functional interaction	Physical interaction	Promoter	Bibliography
TreP132	allows CBP/p300 recruitment	Co-IP, pull-down, two-hybrid	P450scc	[160, 161]
GATA-4	Independent of GATA binding to DNA	Pull-down	MIS	[106, 150]
SOX9	Increases transcription in the presence of SF-1	Two-hybrid, pull-down, co-IP, EMSA	MIS	[105]
WT1-KTS	Activation by WT-1 is dependent on SF-1 binding to its site. No WT-1 binding to DNA	Two-hybrid, GST pull-down	MIS	[107]
Sp1	Cooperation dependent on the cell type	Co-IP, two-hybrid, EMSA	StAR	[202]
Sp1	Cooperation required for basal and cAMP-induced activity. Allows recruitment of CBP	Two-hybrid, EMSA	bovine P450scc	[153, 162]
Egr-1	Synergistic activation. Egr-1 expression is induced by GnRH.	Pull-down	LH-β	[155–157]
Ptx-1	Synergy depends on SF-1 binding to DNA	Pull-down, two-hybrid	LH-β	[158, 159]
CREB	Synergy in basal and cAMP-induced conditions. Allows CBP recuitment	Pull-down	α-Inhibin	[163]
CREB	Synergy in response to cAMP. FSH induces CREB and SF-1 phosphorylation	Not demonstrated	Aromatase	[86, 164]
AP-1/c-jun	Synergy for P450scc and an artificial promoter activation	Pull-down	P450scc and SFRE-tk-CAT	[14, 21]
TF-IIB	No determined	Pull-down		[14]
C/EBPβ	C/EBP binding sites are required for activation by SF-1	Pull-down	mStAR	[112]
USF	USF is required for SF-1 to activate rFSH-R promoter. Activation is inhibited by PKA.	Not demonstrated	rFSH-R	[209]
AR	AR represses LHβ transcription by interacting with SF-1	Pull-down	bLHβ	[154]
DP103	Inhibits SF-1 transcriptional activity by interacting with a proximal repression domain.	Co-IP, pull-down	P450scc, P450c21, progesterone production	[148, 149]
P54^nrb et PSF	Repression of basal and induced hCYP17 promoter activity	EMSA, co-IP	hCYP17	[222]
WT1	Aromatase transcription inhibition. Integrity of the SFRE is required	Not demonstrated	Aromatase	[223]
DAX-1	Inhibits SF-1 transcriptional activity NCoR/Alien recruitment	Pull-down, two-hybrid	Synthetic promoters and SF-1 target genes	[107, 151, 152]

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