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Table 2 A summary of SF-1 target genes. (After Hammer and Ingraham, Ref. [11], updated) The cell types where the studies were conducted are presented. Studies in vivo using transgenic approaches are specified. Basal: SF-1 is required for basal promoter activity of the gene being studied. Induction: SF-1 participates to the cAMP responsiveness of the gene. A different induction signal is stated. N.D. SF-1 implication in the cAMP responsiveness was not determined. Lower case letters before the names of the promoters correspond to the species that were studied (h: human; r: rat; b: bovine; m: mouse).

From: SF-1 a key player in the development and differentiation of steroidogenic tissues

Gene promoter Cell type /Transgenic technique Basal activity/induction by cAMP Bibliography
hP450scc Additive transgenesis, H-295 basal + induction [79, 80]
rP450scc MA-10, rat granulosa basal [138, 188]
bP450scc Y1, bovine luteal cells, COS1 basal + induction [162]
h3β-HSD type II H295, HeLa basal + N.D. [189]
mCYP21 Y1 basal + N.D. [2, 190]
hCYP11B1 Y1, H295 basal + induction [78, 81]
bCYP11B1 Y1, I-10 (Leydig) basal + induction. [191, 192]
hCYP17 H295 basal + induction [47, 82, 183, 185]
bCYP17 Y1, COS-1 basal + induction [83, 84]
rCYP19 R2C, H450, Y1 basal + induction [86, 164, 193, 194]
hCYP19 Bovine luteal cells basal + induction [85]
h/mCYP11B2 H295 inhibition by SF-1 [78]
AKR1-B7 Additive transgenesis, HeLa, CV-1 basal [42, 9092]
HDL-R/SR-BI Y1, HTB9 basal + induction [195198]
SCP2 Y1, HTB9 basal + induction [199]
hStAR Y1, BeWo, H295 basal + induction [200203]
mStAR Y1, MA-10 basal [112]
rStAR Y1, HTB9 (human bladder carcinoma) basal + induction [204]
bStAR HeLa basal + induction [205]
HMG-CoA reductase CV-1, MA-10 basal + N.D. [89]
hMC2R H295-R basal + induction [206, 207]
mMC2R Y1 basal + N.D. [208]
mFSH-R HEK-293 basal [60]
rFSH-R JEG-3 basal + inhibition of PKA induction [209]
rLH-R Granulosa basal inhibition [210]
R-GNRH αT3-1 basal [61, 62, 211, 212]
LHβ Additive transgenesis, LβT2, αT3-1, basal + induction by GnRH in association with Sp1, EGR-1 and Ptx1 [58, 156, 157, 213, 214]
hαGSU LβT2 gonadotropes basal + induction by GnRH [215]
Neuronal mNOS αT3-1, NIH3T3 basal [96]
b-ocytocin TM4 basal [216, 217]
PRL-R MLTC (Leydig) basal [218]
MIS Knock-in mice, HeLa, JEG-3 basal [104, 107, 108]
DAX-1 Additive transgenesis, H295, JEG-3 basal [187, 219221]
RLF/INSL3 MA-10, HeLa, mLTC-1, HEK293 basal [109, 110]
α-inhibin tsa, GRMO2 granulosa basal + induction [163]