From: SF-1 a key player in the development and differentiation of steroidogenic tissues
Organism | Mouse | Human | |
---|---|---|---|
Genotype | SF-1 -/- | SF-1 +/- | SF-1 m/+ ou SF-1 m/m |
Adrenal | - Agenesis | - Histological defects - Hyporesponse to stress - Compensatory growth defects | - Insufficiency (agenesis or dysgenesis) |
Testis | - Agenesis - Sex reversal | Â | - Sex reversal |
Ovary | - Agenesis | Â | - Normal |
VMH | - Agenesis - Obesity caused by absence of the VMH (8 weeks) | Â | Â |
Pituitary | - Defects of gonadotrope cells | Â | Â |