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Figure 5 | Nuclear Receptor

Figure 5

From: SF-1 a key player in the development and differentiation of steroidogenic tissues

Figure 5

Presumed effect of the coactivators p/CIP and TIF2 on SF-1 transactivation. (After Borud et al., Ref. [188]). In the absence of PKA, p/CIP and TIF2 potentiate SF-1 transcriptional activity. When SF-1 is associated to p/CIP, overexpression of PKA induces a marked increase in SF-1 transcriptional activity. On the contrary, PKA overexpression prevents TIF2-dependent potentiation of SF-1 activity. The decrease of TIF2 protein accumulation caused by PKA overexpression may explain these observations. SFRE : SF-1 responsive element.

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