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Figure 3 | Nuclear Receptor

Figure 3

From: Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR

Figure 3

Rexinoid effects on CAR/RXR are dependent on response element. A. HepG2 cells were cotransfected with expression constructs for CAR and/or RXR together with a previously described luciferase construct containing a ER-6 type element from the, human CYP3A4 promoter [16] in the presence or absence of ligands. The luciferase activity presented above is relative to that directed by vector alone in the absence of ligands (100%). B. A similar transfection with a previously described reporter containing the tandem DR-4 elements from the mCYP2B10 gene [16].

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