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Figure 1 | Nuclear Receptor

Figure 1

From: Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR

Figure 1

9-cis RA blocks effects of CAR ligands on coactivator binding in vitro. GST-SRC-3 fusion protein was immobilized on a flow cell and tested for interaction with receptors. A. Overlaid results of injections of apo-RXR and RXR preincubated in the presence of 9-cis RA. B. Overlaid results of injections of apo-CAR and CAR preincubated in the presence of TCPOBOP (TC) or androstanol (An). C. Overlaid results of injections of preformed CAR/RXR heterodimers preincubated in the presence or absence of 9-cis RA and TCPOBOP (TC) as indicated. D. Overlaid results of injections of preformed CAR/RXR heterodimers preincubated in the presence or absence of 9-cis RA and androstanol (An) as indicated.

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